Raisin is a 7-year-old, female spayed, Collie Mix that was referred to us for further treatment after ingestion of a toxic dose of abamectin insecticide (InVict insect paste). This is in the macrolide class of insecticides, and at high doses, crosses the blood-brain barrier, binds to glutamate-gated chloride channels, causes hyperpolarization, prevents nerve conduction, and ultimately can lead to paralysis and death. There is no specific antidote, and traditionally is monitored with supportive care, treatment of seizures, and mechanical ventilation if needed. More recently, intravenous lipid emulsion has become an effective treatment option for animals with toxicities. Continue reading →